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A transcription factor DAF-5 functions in Haemonchus contortus development
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In: Parasit Vectors (2021)
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Voice Onset Time in a Language Without Distinctive Voicing: Blackfoot Oral Stops
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In: Montana-Alberta Conference on Linguistics (mACOL) (2020)
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A DAF-3 co-Smad molecule functions in Haemonchus contortus development
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Di, Wenda; Liu, Lu; Zhang, Ting; Li, Fangfang; He, Li; Wang, Chunqun; Ahmad, Awais Ali; Hassan, Mubashar; Fang, Rui; Hu, Min. - : BioMed Central, 2019
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Abstract:
BACKGROUND: The Smad proteins function in TGF-β signalling transduction. In the model nematode Caenorhabditis elegans, the co-Smad, DAF-3 mediates R-Smads and performs a central role in DAF-7 signal transduction, regulating dauer formation and reproductive processes. Considering the divergent evolutionary patterns of the DAF-7 signalling pathway in parasitic nematodes, it is meaningful to explore the structure and function of DAF-3 in parasitic nematodes, such as Haemonchus contortus. METHODS: A daf-3 gene (Hc-daf-3) and its predicted product (Hc-DAF-3) were identified from H. contortus and characterised using integrated genomic and genetic approaches. In addition to immunohistochemistry employed to localise Hc-DAF-3 within adult worm sections, real-time PCR was conducted to assess the transcriptional profiles in different developmental stages of H. contortus and RNA interference (RNAi) was performed in vitro to assess the functional importance of Hc-daf-3 in the development of H. contortus. RESULTS: Hc-DAF-3 sequences predicted from Hc-daf-3 displayed typical features of the co-Smad subfamily. The native Hc-DAF-3 was localised to the gonad and cuticle of adult parasites. In addition, Hc-daf-3 was transcribed in all developmental stages studied, with a higher level in the third-stage larvae (L3) and adult females. Moreover, silencing Hc-daf-3 by RNAi retarded L4 development. CONCLUSION: The findings of the present study demonstrated an important role of Hc-DAF-3 in the development of H. contortus larvae.
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Keyword:
Research
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935219/ http://www.ncbi.nlm.nih.gov/pubmed/31881930 https://doi.org/10.1186/s13071-019-3855-3
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Articulation Speaks to Executive Function: An Investigation in 4- to 6-Year-Olds
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Bayesian data analysis in the phonetic sciences: A tutorial introduction
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Alveolar and Postalveolar Voiceless Fricative and Affricate Productions of Spanish–English Bilingual Children With Cochlear Implants
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Aligning the timelines of phonological acquisition and change
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The effect of speakers' sex on voice onset time in Mandarin stops
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Language-specific developmental differences in speech production: A cross-language acoustic study
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Language specificity in the perception of voiceless sibilant fricatives in Japanese and English: Implications for cross-language differences in speech-sound development
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Contrast and covert contrast: The phonetic development of voiceless sibilant fricatives in English and Japanese toddlers
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The Phonetic Development of Voiceless Sibilant Fricatives in English, Japanese and Mandarin Chinese
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In: http://rave.ohiolink.edu/etdc/view?acc_num=osu1228250787 (2008)
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